1.2 |
Class: Basic helix-loop-helix factors (bHLH), Alignment |
Aligned bHLH domain sequences: |
RRVANNARERLRVRDINEAFKELGRMCQLHLNSEKP------QTKLLILHQAVSVILNLE E2A
RRMANNARERLRVRDINEAFKELGRMVQLHLKSDKP------QTKLLILHQAVAVILSLE SEF2
RRMANNARERLRVRDINEAFKELGRMCQLHLKSEKP------QTKLLILHQAVAVILSLE HTF4
RRKAATMRERRRLSKVNEAFETLKRCTSSN-PNQ-------RLPKVEILRNAIRYIEGLQ MyoD1
RRRAATLREKRR-KKVNEAFEALKRSTLLN-PNQ-------RLPKVEILRSAIQYIERLQ Myogenin
RRKAATMRERRRLKKVNQAFETLKRCTTTN-PNQ-------RLPKVEILRNAIRYIESLQ Myf5
RRKAATLRERRRLKKINEAFEALKRRTVAN-PNQ-------RLPKVEILRSAISYIERLQ Myf6
AVARRNERERNRVKLVNLGFATLREHV-PNGAAN------KKMSKVETLRSAVEYIRALQ ASH1
AVARRNERERNRVKLVNLGFQALRQHV-PHGGAS------KKLSKVETLRSAVEYIRALQ ASH2
FTRKRNERERQRVKCVNEGYAQLRHHL-PEEYLE------KRLSKVETLRAAIKYINYLQ ASH3
FLRKRNERERQRVRCVNEGYARLRDHL-PRELAD------KRLSKVETLRAAIDYIKHLQ ASH4
FIQKRNERERQRVKCVNEGYARLRGHL-PGALAE------KRLSKVETLRAAIRYIKYLQ ASH5
RRIFTNSRERWRQQNVNGAFAELRKLI-PTHPPD------KKLSKNEILRLAMKYINFLA TAL1
RKIFTNTRERWRQQNVNSAFAKLRKLI-PTHPPD------KKLSKNETLRLAMRYINFLV TAL2
RRVFTNSRERWRQQNVNGAFAELRKLL-PTHPPD------RKLSKNEVLRLAMKYIGFLV Lyl1
YRTAHATRERIRVEAFNLAFAELRKLL-PTLPPD------KKLSKIEILRLAICYISYLN HEN1
YRSAHATRERIRVEAFNLAFAELRKLL-PTLPPD------KKLSKIEILRLAICYISYLN HEN2
QRVMANVRERQRTQSLNEAFAALRKII-PTLPSD-------KLSKIQTLKLAARYIDFLY TWIST1
QRILANVRERQRTQSLNEAFAALRKII-PTLPSD-------KLSKIQTLKLAARYIDFLY TWIST2
RKGSGPKKERRRTESINSAFAELRECI-PNVPAD------TKLSKIKTLRLATSYIAYLM HAND1
RRGTANRKERRRTQSINSAFAELRECI-PNVPAD------TKLSKIKTLRLATSYIAYLM HAND2
QRQAANARERDRTQSVNTAFTALRTLI-PTEPVD------RKLSKIETVRLASSYIAHLA bHLH-EC2
QRHTANARERDRTNSVNTAFTALRTLI-PTEPAD------RKLSKIETLRLASSYISHLG SCX
LRQAANVRERRRMQSINDAFEGLRSHI-PTLPYE------KRLSKVDTLRLAIGYINFLS PTF1A
RRRVANAKERERIKNLNRGFARLKALV-PFLPQS------RKPSKVDILKGATEYIQVLS FIGA
QRQSASEREKLRMRTLARALHELRRFL-PPSVA--PA--GQSLTKIETLRLAIRYIGHLS Mesp1
QRQSASEREKLRMRTLARALHELRRFL-PPSLA--PA--GQSLTKIETLRLAIRYIGHLS Mesp2
ASPENAARERSRVRTLRQAFLALQAAL-PAVPPD------TKLSKLDVLVLAASYIAHLT TCF23
QRNAANARERARMRVLSKAFSRLKTSL-PWVPPD------TKLSKLDTLRLASSYIAHLR ABF1
QRNAANARERARMRVLSKAFSRLKTTL-PWVPPD------TKLSKLDTLRLASSYIAHLR Pod1
RRRKASEREKLRMRTLADALHTLRNYL-PPVYSQR----GQPLTKIQTLKYTIKYIGELT MSGN1
RRMKANARERNRMHGLNAALDNLRKVV-PCYSKT------QKLSKIETLRLAKNYIWALS NeuroD1
RRQKANARERNRMHDLNAALDNLRKVV-PCYSKT------QKLSKIETLRLAKNYIWALS NeuroD2
RRVKANARERTRMHGLNDALDNLRRVM-PCYSKT------QKLSKIETLRLARNYIWALS NeuroD4
RRQEANARERNRMHGLNDALDNLRKVV-PCYSKT------QKLSKIETLRLAKNYIWALS NeuroD6
RRVKANDRERNRMHNLNAALDALRSVL-PSFPDD------TKLTKIETLRFAYNYIWALA NGN1
RRLKANNRERNRMHNLNAALDALREVL-PTFPED------AKLTKIETLRFAHNYIWALT NGN2
RRKKANDRERNRMHNLNSALDALRGVL-PTFPDD------AKLTKIETLRFAHNYIWALT NGN3
RRLAANARERRRMHGLNHAFDQLRNVI-PSFNND------KKLSKYETLQMAQIYINALS ATH1
RRLAANARERRRMQGLNTAFDRLRRVV-PQWGQD------KKLSKYETLQMALSYIMALT ATH5
RRLLANARERTRVHTISAAFEALRKQV-PCYSY------GQKLSKLAILRIACNYILSLA ATH6
LRLNINARERRRMHDLNDALDELRAVI-PY--AHSPSV--RKLSKIATLLLAKNYILMQA bHLHe22
LRLSINARERRRMHDLNDALDGLRAVI-PY--AHSPSV--RKLSKIATLLLAKNYILMQA bHLHe23
LRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLG OLIGO1
LRLKINSRERKRMHDLNIAMDGLREVM-PY--AHGPSV--RKLSKIATLLLARNYILMLT OLIGO2
LRLKINGRERKRMHDLNLAMDGLREVM-PY--AHGPSV--RKLSKIATLLLARNYILMLT OLIGO3
RRLESNERERQRMHKLNNAFQALREVI-PHVRAD------KKLSKIETLTLAKNYIKSLT MIST1
QRQAANIRERKRMFNLNEAFDQLRRKV-PTFAYE------KRLSRIETLRLAIVYISFMT Fer3L
RRMAANVRERKRILDYNEAFNALRRAL-RHDLGG------KRLSKIATLRRAIHRIAALS bHLHa9
RKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHS--KLEKADILEMTVKHLRNLQ HES1
RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCS--KLEKADVLEMTVRFLQELP HES2
-------MEKKRRARINVSLEQLKSLLEKHYSHQIRKR---KLEKADILELSVKYMRSLQ HES3
RKSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHS--KLEKADILEMTVRHLRSLR HES4
NRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNS---KLEKADILEMAVSYLKHSK HES5
RKARKPLVEKKRRARINESLQELRLLLAG-AEVQA------KLENAEVLELTVRRVQGVL HES6
PKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNP--KLEKAEILEFAVGYLRERS HES7
RKRRRGIIEKRRRDRINNSLSELRRLV-PSAFEKQGSA---KLEKAEILQMTVDHLKMLH HEY1
RKKRRGIIEKRRRDRINNSLSELRRLV-PTAFEKQGSA---KLEKAEILQMTVDHLKMLQ HEY2
RKKHRGIIEKRRRDRINSSLSELRRLV-PTAFEKQGSS---KLEKAEVLQMTVDHLKMLH HEYL
YKLPHRLIEKKRRDRINECIAQLKDLL-PEHLKLTTLG---HLEKAVVLELTLKHVKALT DEC1
YKLPHRLIEKKRRDRINECIAQLKDLL-PEHLKLTTLG---HLEKAVVLELTLKHLKALT DEC2
GI-KS-NPSKRHRDRLNTELDRLASLL-PFPQDVIN-----KLDKLSVLRLSVSYLRAKS AhR
GAEKS-NPSKRHRDRLNAELDHLASLL-PFPPDIIS-----KLDKLSVLRLSVSYLRVKS AhRR
MKEKSKNAARTRREKENSEFYELAKLL-PLPSAITS-----QLDKASIIRLTTSYLKMRV SIM1
MKEKSKNAAKTRREKENGEFYELAKLL-PLPSAITS-----QLDKASIIRLTTSYLKMRA SIM2
RKEKSRDAARSRRSKESEVFYELAHQL-PLPHNVSS-----HLDKASVMRLTISYLRVRK HIF1A
RKEKSRDAARSRRSQETEVLYQLAHTL-PFARGVSA-----HLDKASIMRLTISYLRMHR HIF3A
RKEKSRDAARCRRSKETEVFYELAHEL-PLPHSVSS-----HLDKASIMRLAISFLRTHK EPAS1
RKEKSRNAARSRRGKENLEFFELAKLL-PLPGAISS-----QLDKASIVRLSVTYLRLRR NPAS1
RKEKSRDAARSRRGKENFEFYELAKLL-PLPAAITS-----QLDKASIIRLTISYLKMRD NPAS3
ARENHSEIERRRRNKMTAYITELSDMV-PTCSALA-----RKPDKLTILRMAVSHMKSLR Arnt
SRENHSEIERRRRNKMTQYITELSDMV-PTCSALA-----RKPDKLTILRMAVSHMKSMR Arnt2
AREAHSQIEKRRRDKMNSFIDELASLV-PTCNAMS-----RKLDKLTVLRMAVQHMKTLR ArntL
FREAHSQTEKRRRDKMNNLIEELSAMI-PQCNPMA-----RKLDKLTVLRMAVQHLRSLK ArntL2
KRVSRNKSEKKRRDQFNVLIKELGSML-PGNAR--------KMDKSTVLQKSIDFLRKHK CLOCK
KRASRNKSEKKRRDQFNVLIKELSSML-PGNTR--------KMDKTTVLEKVIGFLQKHN NPAS2
CDTLASSTEKRRREQENKYLEELAELLSANISDIDSLS--VKPDKCKILKKTVDQIQLMK NCoA1
GPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFN--FKPDKCAILKETVKQIRQIK NCoA2
GQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFN--VKPDKCAILKETVRQIRQIK NCoA3
MYRSTKGASKARRDQINAEIRNLKELL-PLAEA-----DKVRLSYLHIMSLACIYTRKGV NPAS4
RRNVISERERRKRMSMSLSCERLRALL-PQFD-------GRREDMASVLEMSVQFLRLAS SOHLH1
CLRRNVISERERRKRMSLSCERLRALL-PQFD-------GRREDMASVLEMSVQFLRLAS SOHLH1
ISLLHSSKEKLRRERIKYCCEQLRTLL-PYVK-------GRKNDAASVLEATVDYVKYIR SOHLH2
RERHNRMERDRRRRRIRICCDELNLLV-PFCNA--------ETDKATTLQWTTAFLKYIQ TCFL5
KKDNHNLIERRRRFNINDRIKELGTLI-PKSSDPEM-----RWNKGTILKASVDYIRKLQ TFE3
KKDNHNLIERRRRFNINDRIKELGMLI-PKANDLDV-----RWNKGTILKASVDYIRRMQ TFEB
KKDNHNLIERRRRYNINYRIKELGTLI-PKSNDPDM-----RWNKGTILKASVEYIKWLQ TFEC
KKDNHNLIERRRRFNINDRIKELGTLI-PKSNDPDM-----RWNKGTILKASVDYIRKLQ MITF
RRAQHNEVERRRRDKINNWIVQLSKII-PDCSMEST--KSG-QSKGGILSKACDYIQELR USF1
RRAQHNEVERRRRDKINNWIVQLSKII-PDCNADNS--KTG-ASKGGILSKACDYIRELR USF2
KRTAHNAIEKRYRSSINDKIIELKDLVVGTEA---------KLNKSAVLRKAIDYIRFLQ SREBP1
RRTTHNIIEKRYRSSINDKIIELKDLVMGTDA---------KMHKSGVLRKAIDYIKYLQ SREBP2
RREIANSNERRRMQSINAGFQSLKTLI-PHTDGE-------KLSKAAILQQTAEYIFSLE AP4
KRRTHNVLERQRRNELKRSFFALRDQI-PELENNE------KAPKVVILKKATAYILSVQ CMYC
RRRNHNILERQRRNDLRSSFLTLRDHV-PELVKNE------KAAKVVILKKATEYVHSLQ NMYC
KRKNHNFLERKRRNDLRSRFLALRDQV-PTLASCS------KAPKVVILSKALEYLQALV LMYC1
KKKYHSYLERKRRNDQRSRFLALRDEV-PALASCS------RVSKVMILVKATEYLHELA LMYC2
KRAHHNALERKRRDHIKDSFHSLRDSV-PSLQGE-------KASRAQILDKATEYIQYMR MAX
AHTQAEQKRRRKGDAIKRGYDDLQTIV-PTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLH MLX
RQMKHISAEQKRRFNIKMCFDMLNSLISN---------NSKLTSHAITLQKTVEYITKLQ MLXIP
RRITHISAEQKRRFNIKLGFDTLHGLVSTLS-AQ----PSLKVSKATTLQKTAEYILMLQ WS-bHLH
SRSTHNEMEKNRRAHLRLCLEKLKGLV-PLGPESS------RHTTLSLLTKAKLHIKKLE MAD
GRSVHNELEKRRRAQLKRCLERLKQQM-PLGADCA------RYTTLSLLRRARMHIQKLE MAD3
NRSSHNELEKHRRAKLRLYLEQLKQLV-PLGPDST------RHTTLSLLKRAKVHIKKLE MAD4
YRRTHTANERRRRGEMRDLFEKLKITL-GLLHSS-------KVSKSLILTRAFSEIQGLT MAD5
NRSTHNELEKNRRAHLRLCLERLKVLI-PLGPDCT------RHTTLGLLNKAKAHIKKLE MXI1
TREVHNKLEKNRRAHLKECFETLKRNI-PNVDDK-------KTSNLSVLRTALRYIQSLK MNT