1.2 Class: Basic helix-loop-helix factors (bHLH), Alignment
Aligned bHLH domain sequences:
RRVANNARERLRVRDINEAFKELGRMCQLHLNSEKP------QTKLLILHQAVSVILNLE	E2A
RRMANNARERLRVRDINEAFKELGRMVQLHLKSDKP------QTKLLILHQAVAVILSLE	SEF2
RRMANNARERLRVRDINEAFKELGRMCQLHLKSEKP------QTKLLILHQAVAVILSLE	HTF4
RRKAATMRERRRLSKVNEAFETLKRCTSSN-PNQ-------RLPKVEILRNAIRYIEGLQ	MyoD1
RRRAATLREKRR-KKVNEAFEALKRSTLLN-PNQ-------RLPKVEILRSAIQYIERLQ	Myogenin
RRKAATMRERRRLKKVNQAFETLKRCTTTN-PNQ-------RLPKVEILRNAIRYIESLQ	Myf5
RRKAATLRERRRLKKINEAFEALKRRTVAN-PNQ-------RLPKVEILRSAISYIERLQ	Myf6
AVARRNERERNRVKLVNLGFATLREHV-PNGAAN------KKMSKVETLRSAVEYIRALQ	ASH1
AVARRNERERNRVKLVNLGFQALRQHV-PHGGAS------KKLSKVETLRSAVEYIRALQ	ASH2
FTRKRNERERQRVKCVNEGYAQLRHHL-PEEYLE------KRLSKVETLRAAIKYINYLQ	ASH3
FLRKRNERERQRVRCVNEGYARLRDHL-PRELAD------KRLSKVETLRAAIDYIKHLQ	ASH4
FIQKRNERERQRVKCVNEGYARLRGHL-PGALAE------KRLSKVETLRAAIRYIKYLQ	ASH5
RRIFTNSRERWRQQNVNGAFAELRKLI-PTHPPD------KKLSKNEILRLAMKYINFLA	TAL1
RKIFTNTRERWRQQNVNSAFAKLRKLI-PTHPPD------KKLSKNETLRLAMRYINFLV	TAL2
RRVFTNSRERWRQQNVNGAFAELRKLL-PTHPPD------RKLSKNEVLRLAMKYIGFLV	Lyl1
YRTAHATRERIRVEAFNLAFAELRKLL-PTLPPD------KKLSKIEILRLAICYISYLN	HEN1
YRSAHATRERIRVEAFNLAFAELRKLL-PTLPPD------KKLSKIEILRLAICYISYLN	HEN2
QRVMANVRERQRTQSLNEAFAALRKII-PTLPSD-------KLSKIQTLKLAARYIDFLY	TWIST1
QRILANVRERQRTQSLNEAFAALRKII-PTLPSD-------KLSKIQTLKLAARYIDFLY	TWIST2
RKGSGPKKERRRTESINSAFAELRECI-PNVPAD------TKLSKIKTLRLATSYIAYLM	HAND1
RRGTANRKERRRTQSINSAFAELRECI-PNVPAD------TKLSKIKTLRLATSYIAYLM	HAND2
QRQAANARERDRTQSVNTAFTALRTLI-PTEPVD------RKLSKIETVRLASSYIAHLA	bHLH-EC2 
QRHTANARERDRTNSVNTAFTALRTLI-PTEPAD------RKLSKIETLRLASSYISHLG	SCX
LRQAANVRERRRMQSINDAFEGLRSHI-PTLPYE------KRLSKVDTLRLAIGYINFLS	PTF1A
RRRVANAKERERIKNLNRGFARLKALV-PFLPQS------RKPSKVDILKGATEYIQVLS	FIGA
QRQSASEREKLRMRTLARALHELRRFL-PPSVA--PA--GQSLTKIETLRLAIRYIGHLS	Mesp1
QRQSASEREKLRMRTLARALHELRRFL-PPSLA--PA--GQSLTKIETLRLAIRYIGHLS	Mesp2
ASPENAARERSRVRTLRQAFLALQAAL-PAVPPD------TKLSKLDVLVLAASYIAHLT	TCF23
QRNAANARERARMRVLSKAFSRLKTSL-PWVPPD------TKLSKLDTLRLASSYIAHLR	ABF1
QRNAANARERARMRVLSKAFSRLKTTL-PWVPPD------TKLSKLDTLRLASSYIAHLR	Pod1
RRRKASEREKLRMRTLADALHTLRNYL-PPVYSQR----GQPLTKIQTLKYTIKYIGELT	MSGN1
RRMKANARERNRMHGLNAALDNLRKVV-PCYSKT------QKLSKIETLRLAKNYIWALS	NeuroD1
RRQKANARERNRMHDLNAALDNLRKVV-PCYSKT------QKLSKIETLRLAKNYIWALS	NeuroD2
RRVKANARERTRMHGLNDALDNLRRVM-PCYSKT------QKLSKIETLRLARNYIWALS	NeuroD4
RRQEANARERNRMHGLNDALDNLRKVV-PCYSKT------QKLSKIETLRLAKNYIWALS	NeuroD6
RRVKANDRERNRMHNLNAALDALRSVL-PSFPDD------TKLTKIETLRFAYNYIWALA	NGN1
RRLKANNRERNRMHNLNAALDALREVL-PTFPED------AKLTKIETLRFAHNYIWALT	NGN2
RRKKANDRERNRMHNLNSALDALRGVL-PTFPDD------AKLTKIETLRFAHNYIWALT	NGN3
RRLAANARERRRMHGLNHAFDQLRNVI-PSFNND------KKLSKYETLQMAQIYINALS	ATH1
RRLAANARERRRMQGLNTAFDRLRRVV-PQWGQD------KKLSKYETLQMALSYIMALT	ATH5
RRLLANARERTRVHTISAAFEALRKQV-PCYSY------GQKLSKLAILRIACNYILSLA	ATH6
LRLNINARERRRMHDLNDALDELRAVI-PY--AHSPSV--RKLSKIATLLLAKNYILMQA	bHLHe22 
LRLSINARERRRMHDLNDALDGLRAVI-PY--AHSPSV--RKLSKIATLLLAKNYILMQA	bHLHe23 
LRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLG	OLIGO1
LRLKINSRERKRMHDLNIAMDGLREVM-PY--AHGPSV--RKLSKIATLLLARNYILMLT	OLIGO2
LRLKINGRERKRMHDLNLAMDGLREVM-PY--AHGPSV--RKLSKIATLLLARNYILMLT	OLIGO3
RRLESNERERQRMHKLNNAFQALREVI-PHVRAD------KKLSKIETLTLAKNYIKSLT	MIST1
QRQAANIRERKRMFNLNEAFDQLRRKV-PTFAYE------KRLSRIETLRLAIVYISFMT 	Fer3L 
RRMAANVRERKRILDYNEAFNALRRAL-RHDLGG------KRLSKIATLRRAIHRIAALS	bHLHa9 
RKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHS--KLEKADILEMTVKHLRNLQ	HES1
RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCS--KLEKADVLEMTVRFLQELP	HES2
-------MEKKRRARINVSLEQLKSLLEKHYSHQIRKR---KLEKADILELSVKYMRSLQ	HES3
RKSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHS--KLEKADILEMTVRHLRSLR	HES4
NRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNS---KLEKADILEMAVSYLKHSK	HES5
RKARKPLVEKKRRARINESLQELRLLLAG-AEVQA------KLENAEVLELTVRRVQGVL	HES6
PKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNP--KLEKAEILEFAVGYLRERS	HES7
RKRRRGIIEKRRRDRINNSLSELRRLV-PSAFEKQGSA---KLEKAEILQMTVDHLKMLH	HEY1
RKKRRGIIEKRRRDRINNSLSELRRLV-PTAFEKQGSA---KLEKAEILQMTVDHLKMLQ	HEY2
RKKHRGIIEKRRRDRINSSLSELRRLV-PTAFEKQGSS---KLEKAEVLQMTVDHLKMLH	HEYL
YKLPHRLIEKKRRDRINECIAQLKDLL-PEHLKLTTLG---HLEKAVVLELTLKHVKALT	DEC1 
YKLPHRLIEKKRRDRINECIAQLKDLL-PEHLKLTTLG---HLEKAVVLELTLKHLKALT	DEC2 
GI-KS-NPSKRHRDRLNTELDRLASLL-PFPQDVIN-----KLDKLSVLRLSVSYLRAKS	AhR
GAEKS-NPSKRHRDRLNAELDHLASLL-PFPPDIIS-----KLDKLSVLRLSVSYLRVKS	AhRR
MKEKSKNAARTRREKENSEFYELAKLL-PLPSAITS-----QLDKASIIRLTTSYLKMRV	SIM1
MKEKSKNAAKTRREKENGEFYELAKLL-PLPSAITS-----QLDKASIIRLTTSYLKMRA	SIM2
RKEKSRDAARSRRSKESEVFYELAHQL-PLPHNVSS-----HLDKASVMRLTISYLRVRK	HIF1A
RKEKSRDAARSRRSQETEVLYQLAHTL-PFARGVSA-----HLDKASIMRLTISYLRMHR	HIF3A
RKEKSRDAARCRRSKETEVFYELAHEL-PLPHSVSS-----HLDKASIMRLAISFLRTHK	EPAS1
RKEKSRNAARSRRGKENLEFFELAKLL-PLPGAISS-----QLDKASIVRLSVTYLRLRR	NPAS1
RKEKSRDAARSRRGKENFEFYELAKLL-PLPAAITS-----QLDKASIIRLTISYLKMRD	NPAS3
ARENHSEIERRRRNKMTAYITELSDMV-PTCSALA-----RKPDKLTILRMAVSHMKSLR	Arnt
SRENHSEIERRRRNKMTQYITELSDMV-PTCSALA-----RKPDKLTILRMAVSHMKSMR	Arnt2
AREAHSQIEKRRRDKMNSFIDELASLV-PTCNAMS-----RKLDKLTVLRMAVQHMKTLR	ArntL
FREAHSQTEKRRRDKMNNLIEELSAMI-PQCNPMA-----RKLDKLTVLRMAVQHLRSLK	ArntL2
KRVSRNKSEKKRRDQFNVLIKELGSML-PGNAR--------KMDKSTVLQKSIDFLRKHK	CLOCK
KRASRNKSEKKRRDQFNVLIKELSSML-PGNTR--------KMDKTTVLEKVIGFLQKHN	NPAS2
CDTLASSTEKRRREQENKYLEELAELLSANISDIDSLS--VKPDKCKILKKTVDQIQLMK	NCoA1
GPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFN--FKPDKCAILKETVKQIRQIK	NCoA2
GQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFN--VKPDKCAILKETVRQIRQIK	NCoA3
MYRSTKGASKARRDQINAEIRNLKELL-PLAEA-----DKVRLSYLHIMSLACIYTRKGV	NPAS4
RRNVISERERRKRMSMSLSCERLRALL-PQFD-------GRREDMASVLEMSVQFLRLAS	SOHLH1
CLRRNVISERERRKRMSLSCERLRALL-PQFD-------GRREDMASVLEMSVQFLRLAS	SOHLH1
ISLLHSSKEKLRRERIKYCCEQLRTLL-PYVK-------GRKNDAASVLEATVDYVKYIR	SOHLH2
RERHNRMERDRRRRRIRICCDELNLLV-PFCNA--------ETDKATTLQWTTAFLKYIQ	TCFL5
KKDNHNLIERRRRFNINDRIKELGTLI-PKSSDPEM-----RWNKGTILKASVDYIRKLQ	TFE3
KKDNHNLIERRRRFNINDRIKELGMLI-PKANDLDV-----RWNKGTILKASVDYIRRMQ	TFEB
KKDNHNLIERRRRYNINYRIKELGTLI-PKSNDPDM-----RWNKGTILKASVEYIKWLQ	TFEC
KKDNHNLIERRRRFNINDRIKELGTLI-PKSNDPDM-----RWNKGTILKASVDYIRKLQ	MITF
RRAQHNEVERRRRDKINNWIVQLSKII-PDCSMEST--KSG-QSKGGILSKACDYIQELR	USF1
RRAQHNEVERRRRDKINNWIVQLSKII-PDCNADNS--KTG-ASKGGILSKACDYIRELR	USF2
KRTAHNAIEKRYRSSINDKIIELKDLVVGTEA---------KLNKSAVLRKAIDYIRFLQ	SREBP1
RRTTHNIIEKRYRSSINDKIIELKDLVMGTDA---------KMHKSGVLRKAIDYIKYLQ	SREBP2
RREIANSNERRRMQSINAGFQSLKTLI-PHTDGE-------KLSKAAILQQTAEYIFSLE	AP4
KRRTHNVLERQRRNELKRSFFALRDQI-PELENNE------KAPKVVILKKATAYILSVQ	CMYC
RRRNHNILERQRRNDLRSSFLTLRDHV-PELVKNE------KAAKVVILKKATEYVHSLQ	NMYC
KRKNHNFLERKRRNDLRSRFLALRDQV-PTLASCS------KAPKVVILSKALEYLQALV	LMYC1
KKKYHSYLERKRRNDQRSRFLALRDEV-PALASCS------RVSKVMILVKATEYLHELA	LMYC2
KRAHHNALERKRRDHIKDSFHSLRDSV-PSLQGE-------KASRAQILDKATEYIQYMR	MAX
AHTQAEQKRRRKGDAIKRGYDDLQTIV-PTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLH	MLX
RQMKHISAEQKRRFNIKMCFDMLNSLISN---------NSKLTSHAITLQKTVEYITKLQ	MLXIP
RRITHISAEQKRRFNIKLGFDTLHGLVSTLS-AQ----PSLKVSKATTLQKTAEYILMLQ	WS-bHLH 
SRSTHNEMEKNRRAHLRLCLEKLKGLV-PLGPESS------RHTTLSLLTKAKLHIKKLE	MAD
GRSVHNELEKRRRAQLKRCLERLKQQM-PLGADCA------RYTTLSLLRRARMHIQKLE	MAD3
NRSSHNELEKHRRAKLRLYLEQLKQLV-PLGPDST------RHTTLSLLKRAKVHIKKLE	MAD4
YRRTHTANERRRRGEMRDLFEKLKITL-GLLHSS-------KVSKSLILTRAFSEIQGLT	MAD5
NRSTHNELEKNRRAHLRLCLERLKVLI-PLGPDCT------RHTTLGLLNKAKAHIKKLE	MXI1
TREVHNKLEKNRRAHLKECFETLKRNI-PNVDDK-------KTSNLSVLRTALRYIQSLK 	MNT